2026.2·Finding stability

Most of the past six weeks went into infrastructure. Authentication, database migrations, a new import engine. Important work, but not the kind of thing you notice as a user. So let me focus on what you will notice.

We shipped our first community tool with real experimental and scientific value: a Reference Gene Finder based on the geNorm algorithm.

Find your most stable reference genes

Choosing the right reference genes is one of those decisions that impact the quality of your entire qPCR experiment. The geNorm algorithm, Vandesompele et al. (2002), solves this by ranking candidates by expression stability. Now that qbase+ is no longer available, we decided to step in and offer a community tool to assist researchers in identifying stably expressed reference genes.

Our Reference Gene Finder brings this algorithm to the browser. Paste your Cq data, and within seconds you see which genes are most stable across your samples, how many reference genes you actually need, and where the diminishing returns kick in. Free for all, convenient and with a fresh look.

• Unified file import · Every tool in Clarida now shares the same import engine. Drag and drop works the same whether you are in the platform, the plate homogeneity tool, or the Reference Gene Finder. Under the hood, we replaced SheetJS with ExcelJS for better reliability with large files and addressing an unlikely vulnerability.
• Interactive charts · Measurement data now renders as interactive Plotly charts. Hover for values, zoom into regions of interest, export as PNG. A step up from the static images in 2026.1.
• User accounts and workspaces · Clarida now has proper authentication. Sign in, and your experiments persist across sessions.
• Community tools in one place · The plate homogeneity tool, concentration converter, and Reference Gene Finder now live together at clarida.com/tools. Easier to find, easier to bookmark.
• Smoother note-taking · Experiment notes no longer reset your cursor when auto-saving. A small fix, but one you would have noticed every time you typed a longer observation.
• Heatmap color fix · Wells with missing Ct values in the plate homogeneity tool now display correctly instead of breaking the color scale.